[Efficacy of headache powder]_action_effect

[Efficacy of headache powder]_action_effect

When we are exhausted, we often feel very headache. Especially for office workers, they often stay up late to plan overtime, there is no regular lifestyle, and the diet cannot be reasonably arranged.
Headaches are a common symptom, so choose a medicine to treat it effectively.
The headache powder is a good choice, it is a special medicine for headaches.
Here is the effect of headache powder.
1. Paracetamol in this product mainly produces analgesic effects by inhibiting prostaglandin synthesis (inhibiting prostaglandin synthetase) and blocking the impulse of pain sensory nerve endings, which may be related to inhibiting prostaglandin or other substances that can cause pain.The synthesis of body-sensitive substances (such as 5-hydrotryptamine, bradykinin, etc.).
The antipyretic effect is to produce peripheral vasodilation through the hypothalamic body temperature regulation center, and to increase the skin’s blood flow, sweating and heat loss.
2. Aspirin can inhibit the synthesis of prostaglandins and produce antipyretic and analgesic effects: the analgesic effect is through the inhibition of prostaglandins and other substances that can make pain sense sensitive to mechanical or chemical stimuli (such as bradykinin, histamine).Synthetic, belongs to peripheral analgesics.
However, the possibility of central analgesia (which may act on the hypothalamus) cannot be ruled out.
The antipyretic effect is to inhibit the synthesis of prostaglandins in the hypothalamus.
Caffeine is a central stimulant that can constrict the cerebral blood vessels and reduce the amplitude of its pulsation. Compatibility with antipyretic and analgesics can increase the analgesic effect.
Three.This product should not be taken with alcoholic beverages, barbiturates (such as phenobarbital), and antispasmodics (such as belladonna), as it can cause liver damage.
2.When this product is used in combination with the antiviral drug Zidovudine, the two drugs can reduce the clearance with glucuronic acid and reduce its clearance rate, thereby increasing its toxicity. Therefore, simultaneous application should be avoided.
3.This product should not be used with anticoagulant drugs (such as dicoumarin, heparin), thrombolytic drugs and corticosteroids.
4.Antacids such as sodium bicarbonate can increase the excretion of aspirin in the urine and reduce the concentration of blood drug, so it should not be used together.
5.This product can strengthen the effect of oral hypoglycemic drugs and methotrexate, and should not be used together.
6.Isoniazid and meprobamate can promote the effectiveness of caffeine in this product, increasing the latter’s concentration in the brain tissue by 55%, while the concentration in the liver and kidney has decreased.
7.Oral contraceptives have the potential to slow caffeine clearance.
8.Glucocorticoids (hormones for short) can increase the excretion of salicylates. In order to maintain the blood concentration of the product, the dose of the product should be increased when necessary.
This product is used together with hormones for a long time, especially when it is used in large quantities, which increases the risk of gastrointestinal ulcers and bleeding.
For this reason, the simultaneous application of these two drugs is not advocated in clinical practice.
9.The uric acid effect of probenecid or sulfinpyrazone can be reduced due to the simultaneous application of this product; when the salicylate concentration is greater than 50 μg / ml, it is significantly reduced, and more than 100-150 μg / mlvery.
In addition, probenecid can reduce salicylate clearance from the kidneys, thereby increasing the plasma concentration of the latter.